Bird A V, Satoyoshi E
J Neurol Neurosurg Psychiatry. 1975 Sep;38(9):911-8. doi: 10.1136/jnnp.38.9.911.
Evidence is presented pointing to an increased incidence of multiple sclerosis having taken place in South Africa during the period 1964 to 1970 and in Tokyo, Japan, during the period 1966 to 1972. There is a possibility that these changes in incidence point to the introduction during the years immediately after the second world war, of an infective element-probably from a high-risk area-to Tokyo and South Africa. If this is so, it lends support to the theory of an infective basis for multiple sclerosis and that the suspected infection in prepubertal susceptibles may produce the symptoms of multiple sclerosis years later. Other factors relevant to multiple sclerosis such as environmental changes, improved diagnostic techniques, and susceptibility are discussed.
有证据表明，1964年至1970年期间南非以及1966年至1972年期间日本东京的多发性硬化症发病率有所上升。发病率的这些变化有可能表明，在第二次世界大战刚结束后的几年里，一种感染因素——可能来自高风险地区——被引入了东京和南非。如果真是这样，这就支持了多发性硬化症有感染基础的理论，即青春期前易感人群中疑似感染可能在数年之后引发多发性硬化症的症状。文中还讨论了与多发性硬化症相关的其他因素，如环境变化、诊断技术的改进以及易感性。
