Buchman Nili, Strous Rael D, Baruch Yehuda
Beer Yaakov Mental Health Center, Sackler School of Medicine, Tel Aviv University, Beer Yaakov, Israel.
Clin Neuropharmacol. 2002 Jan-Feb;25(1):55-7. doi: 10.1097/00002826-200201000-00010.
Depressive disorders are frequently managed with long-term use of antidepressant medication. Even though the newer generation of selective serotonin reuptake inhibitor antidepressants exhibits a more favorable short-term, side-effect profile, effects of chronic use of such drugs remain unknown. Considering the limited data available on long-term, selective serotonin reuptake inhibitor management, we report for the first time on two cases of late-onset adverse effects occurring 6 and 10 years after chronic-fluoxetine treatment in which patients experienced symptoms of restlessness, tension, agitation, and sleep disturbances. Symptoms resolved after reduction or cessation of the medication. Our case reports suggest the existence of a late-onset side-effect profile, which appears similar to acute side-effect symptomatology. Super sensitivity of the serotonin-related receptors may develop over the long-term and account for the phenomenon. Careful clinical monitoring is recommended to detect any late-onset, medication-related side effects.
抑郁症常常通过长期使用抗抑郁药物来治疗。尽管新一代选择性5-羟色胺再摄取抑制剂抗抑郁药在短期副作用方面表现更佳，但长期使用这类药物的影响仍不明确。鉴于关于长期使用选择性5-羟色胺再摄取抑制剂治疗的数据有限，我们首次报告了两例在长期服用氟西汀6年和10年后出现迟发性不良反应的病例，患者出现了坐立不安、紧张、激动和睡眠障碍等症状。减少或停用药物后症状消失。我们的病例报告表明存在迟发性副作用，其表现似乎与急性副作用症状相似。5-羟色胺相关受体的超敏反应可能会在长期使用过程中出现，并解释了这一现象。建议进行仔细的临床监测，以发现任何迟发性、与药物相关的副作用。
