[HIV合并结核病患者CD4淋巴细胞与病毒载量的相关性]

[Correlation between CD4 lymphocytes and viral load in patients with HIV and tuberculosis].

作者信息

Lado Lado F L, Prieto Martínez A, Losada Arias E, Cabarcos Ortiz de Barrón A, Aguilera Guirao A, Pérez del Molino M L

机构信息

Servicio de Medicina Interna, Unidad de SIDA, Hospital Clínico Universitario, 15706 Santiago de Compostela, LA Coruña.

出版信息

An Med Interna. 2001 Dec;18(12):624-8.

PMID:11852497

Abstract

OBJECTIVE

A retrospective study of the correlation between CD4 lymphocytes and the viral load in 16 HIV-patients with tuberculosis.

MATERIAL AND METHODS

The clinical forms of presentation of tuberculosis were classified according to the location/s of the disease into: pulmonary, distinguishing between typical pulmonary and atypical according to the radiological pattern; extrapulmonary; mixed forms: pulmonary and extrapulmonary; and miliary tuberculosis.

RESULTS

Tuberculosis was exclusively pulmonary in 7 cases (44%), all were atypical; extrapulmonary 6 (38%); mixed 2 (12%); and miliary 1 (6%). The mean CD4 lymphocyte count was 111.1 (range 5-360), in 11 (69%) the counts were below 200 cells/mm3. The lowest CD4 count was in the mixed forms with a mean of 45 cells/mm3 whilst the highest was obtained in pulmonary forms with a mean of 128.3 cells/mm3. The mean viral load was 4.82 log (range, 0-5.93), the highest load was for mixed forms with a mean 5.69 log, whereas the lowest load was for pulmonary forms with a mean of 4.19 log. No significant correlation was observed between CD4 lymphocytes and viral load (correlation coefficient--0.1163).

CONCLUSIONS

Though no significant correlation was observed, a high CD4 was associated to a low viral load and inversely a low CD4 with a high viral load.

摘要

目的

对16例合并肺结核的HIV患者的CD4淋巴细胞与病毒载量之间的相关性进行回顾性研究。

材料与方法

根据疾病部位将肺结核的临床症状表现分为：肺部，根据放射学模式区分典型肺部和非典型肺部；肺外；混合形式：肺部和肺外；以及粟粒性肺结核。

结果

7例（44%）肺结核仅为肺部感染，均为非典型；肺外6例（38%）；混合2例（12%）；粟粒性1例（6%）。CD4淋巴细胞平均计数为111.1（范围5 - 360），11例（69%）计数低于200个细胞/mm³。最低CD4计数出现在混合形式中，平均为45个细胞/mm³，而最高出现在肺部形式中，平均为128.3个细胞/mm³。平均病毒载量为4.82 log（范围，0 - 5.93），最高载量出现在混合形式中，平均为5.69 log，而最低载量出现在肺部形式中，平均为4.19 log。未观察到CD4淋巴细胞与病毒载量之间存在显著相关性（相关系数 - 0.1163）。