Sy W M, Westring D W, Weinberger G
J Nucl Med. 1975 Nov;16(11):1013-6.
Photon-deficient foci or "cold" lesions were demonstrated on 99mTc-polyphosphate bone imaging in eight individuals with various malignancies and one in sickle cell crisis. The bone radiographs of five of these persons failed to show corresponding bony changes at the time of the imaging. Most of the "cold" lesions observed on bone imaging were located in the denser and tubular bones. A postulate has been advanced regarding the factors that might influence the different gamma-imaging manifestations of radiographically demonstrable lytic lesions. The cases presented herein further emphasize the importance of recognizing the existence of "cold" areas in the images of bones and the need to place these in proper perspective when interpreting scans.
在99mTc-多聚磷酸盐骨显像中，8例患有各种恶性肿瘤的患者及1例镰状细胞危象患者出现了光子缺乏灶或“冷”性病变。其中5例患者的骨X光片在显像时未显示相应的骨质改变。骨显像中观察到的大多数“冷”性病变位于密度较高的管状骨中。关于可能影响影像学上可显示的溶骨性病变不同伽马显像表现的因素，已提出一种假说。本文所呈现的病例进一步强调了在骨影像中识别“冷”区存在的重要性，以及在解读扫描结果时正确看待这些区域的必要性。
