Stewart C N, Coursin D B, Bhagavan H N
J Nutr. 1975 Nov;105(11):1363-70. doi: 10.1093/jn/105.11.1363.
Pyridoxine deficiency was induced during the postweaning period in infant and young adult male rats and the effects on active avoidance and escape learning were studied. Five weeks of pyridoxine deficiency was sufficient to produce a deficit in active avoidance learning in the postweanling animals, whereas up to 10 weeks of deficient diet ingestion produced no effect on young adult animals. Mild motor impairment was produced in the young pyridoxine-deficient rats but the avoidance learning deficit could not be explained away on this basis, because a deficit in passive avoidance was also produced by the deficiency. Reversal of the deficiency by pyridoxine injection restored the active avoidance learning to normal within 1 week.
在幼龄和成年雄性大鼠断奶后的时期诱导维生素B6缺乏，并研究其对主动回避和逃避学习的影响。五周的维生素B6缺乏足以使断奶后动物的主动回避学习出现缺陷，而长达十周的缺乏饮食摄入对成年动物没有影响。维生素B6缺乏的幼龄大鼠出现了轻度运动障碍，但回避学习缺陷不能以此来解释，因为这种缺乏也导致了被动回避的缺陷。通过注射维生素B6纠正缺乏，可在1周内使主动回避学习恢复正常。
