Bunyaratavej N, Kitimanon N, Tunjariyanond K
Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2001 Oct;84 Suppl 2:S582-5.
Study of the effect of calcitriol (Rocaltrol) to bone markers and PTH level in 146 menopausal women. The result showed a dose of calcitriol 0.75 microgram/day for one month significantly decreased the level of PTH, bone marker for resorption and NMID osteocalcin 61.55, 69.92, 60.02 per cent respectively (p=0.000). The other group which took calcitriol 0.5 microgram/day had little change to such markers. The active form of vitamin D benefits bone health by enhancing osteocalcin formation, in addition vitamin D has moderate antiresorption and suppression of PTH secretion.
对146名绝经后女性进行骨化三醇（罗钙全）对骨标志物和甲状旁腺激素水平影响的研究。结果显示，每天服用0.75微克骨化三醇，持续一个月，可使甲状旁腺激素水平、骨吸收标志物和N-端中段骨钙素分别显著降低61.55%、69.92%和60.02%（p = 0.000）。另一组每天服用0.5微克骨化三醇，这些标志物变化不大。维生素D的活性形式通过增强骨钙素的形成而有益于骨骼健康，此外，维生素D具有适度的抗吸收作用并能抑制甲状旁腺激素的分泌。
