Orosco Martine, Rouch Claude, Daugé Valérie
Physiopathologie de la Nutrition, CNRS ESA 7059, Université Paris 7, 2, Place Jussieu, 75251 Paris, Cedex 05, France.
Behav Brain Res. 2002 Apr 15;132(1):103-9. doi: 10.1016/s0166-4328(01)00397-7.
In previous experiments, we described a decrease in extracellular hypothalamic serotonin, 5-hydroxy-tryptamine (5-HT), in response to ingestion of a lard meal. This effect was related to the low satiating potency of lard as compared with other nutrients. Since the composition in fatty acids might be important for these effects, the purpose of this study was to analyze the neurochemical and behavioral responses to ingestion of different sources of fat. Unique meals of three margarines used in human feeding were compared with a meal of lard with regard to their effects on hypothalamic 5-HT, satiety, anxiety-like behavior and sucrose consumption. A vegetable margarine with a high content in saturated fatty acids also decreased hypothalamic 5-HT while ingestion of a sunflower oil and an olive oil enriched margarines, both high in polyunsaturated fatty acids, did not affect significantly 5-HT levels. However, these two last ones were not the most satiating. The olive oil margarine induced a tendency to an anxiety-like behavior while lard increased sucrose consumption. Thus, ingestion of fats may alter specifically behavioral responses. The involvement of 5-HT is likely in the case of lard ingestion but probably not for the other sources of fat.
在之前的实验中，我们描述了摄入猪油餐会导致细胞外下丘脑5-羟色胺（5-HT）减少。这种效应与猪油相较于其他营养物质的低饱腹感有关。由于脂肪酸组成可能对这些效应很重要，本研究的目的是分析摄入不同来源脂肪后的神经化学和行为反应。将用于人类喂养的三种人造黄油的特制餐与猪油餐在对下丘脑5-HT、饱腹感、焦虑样行为和蔗糖消耗的影响方面进行了比较。一种饱和脂肪酸含量高的植物人造黄油也会降低下丘脑5-HT，而摄入富含多不饱和脂肪酸的向日葵油和橄榄油强化人造黄油则对5-HT水平没有显著影响。然而，后两者并不是最具饱腹感的。橄榄油人造黄油会引发类似焦虑的行为倾向，而猪油会增加蔗糖消耗。因此，摄入脂肪可能会特异性地改变行为反应。摄入猪油的情况下5-HT可能参与其中，但其他脂肪来源可能并非如此。
