Webb A J, Eveson J W
Department of Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Oral Oncol. 2002 Feb;38(2):163-71. doi: 10.1016/s1368-8375(01)00040-9.
This is a study of 33 (32 patients) confirmed Warthin's tumours (adenolymphomas) treated surgically at Bristol Royal Infirmary (1985--1995) focussing specifically upon 17 salient histopathological features together with capsular measurement by micrometry. Twenty-four out of 33 tumours had 'thin' capsules (< or = 200 microm), whereas 5/9 'thick' capsules were associated with gross tumour degeneration. The degenerative features including cystic change, squamous metaplasia, corpora amylacea like bodies, etc. were quantified. Tumours were classified into subtypes (typical, stroma poor, etc). These variations were not associated with age or sex. In 20/33 tumours a marginal sinus suggested a lymph node origin. Fine needle aspiration cytology (FNA) smears showing degeneration features are a diagnostic problem, but histopathological features are reflected in such smears and their recognition enhances diagnostic precision, enabling controlled surgical enucleation, the ideal operation, to be performed in most cases. In this study only 12 tumours were so treated; 11 others received parotidectomy. The theories of histogenesis are reviewed and discussed.
这是一项针对在布里斯托尔皇家医院（1985 - 1995年）接受手术治疗的33例（32名患者）确诊沃辛瘤（腺淋巴瘤）的研究，特别关注17项显著的组织病理学特征以及通过显微镜测量的包膜尺寸。33例肿瘤中有24例具有“薄”包膜（≤200微米），而9例“厚”包膜中有5例与肿瘤大体退变相关。对包括囊性变、鳞状化生、类淀粉样小体等退变特征进行了量化。肿瘤被分为不同亚型（典型型、间质少型等）。这些差异与年龄或性别无关。33例肿瘤中有20例边缘窦提示淋巴结起源。细针穿刺细胞学（FNA）涂片显示退变特征是一个诊断难题，但组织病理学特征在这类涂片中有所体现，对其识别可提高诊断准确性，从而在大多数情况下能够进行理想的手术——控制性手术摘除。在本研究中，只有12例肿瘤接受了这样的治疗；另外11例接受了腮腺切除术。对组织发生学理论进行了回顾和讨论。
