Kumar Sanjai, Epstein Judith E, Richie Thomas L, Nkrumah Francis K, Soisson Lorraine, Carucci Daniel J, Hoffman Stephen L
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA.
Trends Parasitol. 2002 Mar;18(3):129-35. doi: 10.1016/s1471-4922(01)02207-3.
Scientists from several organizations worldwide are working together to develop a multistage, multigene DNA-based vaccine against Plasmodium falciparum malaria. This collaborative vaccine development effort is named Multi-Stage DNA-based Malaria Vaccine Operation. An advisory board of international experts in vaccinology, malariology and field trials provides the scientific oversight to support the operation. This article discusses the rationale for the approach, underlying concepts and the pre-clinical development process, and provides a brief outline of the plans for the clinical testing of a multistage, multiantigen malaria vaccine based on DNA plasmid immunization technology.
来自全球多个组织的科学家正在共同努力，研发一种针对恶性疟原虫疟疾的多阶段、多基因DNA疫苗。这项合作疫苗研发工作被命名为多阶段DNA疟疾疫苗行动。一个由疫苗学、疟疾学和现场试验方面的国际专家组成的顾问委员会提供科学监督，以支持该行动。本文讨论了该方法的基本原理、潜在概念和临床前研发过程，并简要概述了基于DNA质粒免疫技术的多阶段、多抗原疟疾疫苗的临床试验计划。
