准稳态和非稳态条件下的生物利用度评估。I：理论考量。

Bioavailability assessment under quasi- and nonsteady-state conditions. I: theoretical considerations.

作者信息

Kwan K C, Bondi J V, Yeh K C

出版信息

J Pharm Sci. 1975 Oct;64(10):1639-42. doi: 10.1002/jps.2600641010.

Abstract

A strategy was devised to permit bioavailability estimations at quasi- and nonsteady states. The proposed method retains most attributes of a steady-state comparison without being burdened by its protractiveness. The only necessary requirements are that drug disposition obeys linear kinetics and that succeeding doses are administered during the log-linear phase free from the influence of continuing absorption.

摘要

设计了一种策略，以允许在准稳态和非稳态下进行生物利用度估计。所提出的方法保留了稳态比较的大多数属性，而不会受到其冗长性的困扰。唯一必要的要求是药物处置遵循线性动力学，并且后续剂量在对数线性期内给药，不受持续吸收的影响。