法莫替丁和西咪替丁对正常志愿者体内茶碱药代动力学的比较效应。
Comparative effect of famotidine and cimetidine on the pharmacokinetics of theophylline in normal volunteers.
作者信息
Lin J H, Chremos A N, Chiou R, Yeh K C, Williams R
机构信息
Department of Drug Metabolism, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486.
出版信息
Br J Clin Pharmacol. 1987 Nov;24(5):669-72. doi: 10.1111/j.1365-2125.1987.tb03228.x.
Abstract
The comparative effect of famotidine or cimetidine on theophylline disposition was determined in healthy volunteers. Cimetidine, but not famotidine, caused a reduction in the rate of elimination of theophylline. The mean total body clearance of theophylline was reduced from 57.6 ml min-1 before cimetidine to 39.5 ml min-1 during cimetidine; and the half-life was prolonged from 8.7 h before cimetidine to 12 h during cimetidine. The volume of distribution and renal excretion of theophylline were not affected by either famotidine or cimetidine.
摘要
在健康志愿者中测定了法莫替丁或西咪替丁对茶碱处置的比较效果。西咪替丁而非法莫替丁导致茶碱消除速率降低。茶碱的平均全身清除率在服用西咪替丁前为57.6 ml/min，服用西咪替丁期间降至39.5 ml/min；半衰期从服用西咪替丁前的8.7小时延长至服用西咪替丁期间的12小时。法莫替丁和西咪替丁均未影响茶碱的分布容积和肾排泄。
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