含有胆固醇和二棕榈酰卵磷脂的单分子层中的分子排列
Molecular arrangement in monolayers containing cholesterol and dipalmitoyl lecithin.
作者信息
Zatz J L, Cleary G W
出版信息
J Pharm Sci. 1975 Sep;64(9):1534-7. doi: 10.1002/jps.2600640925.
PMID:1185574
Abstract
The molecular arrangement of dipalmitoyl lecithin and cholesterol in mixed monolayers was investigated with the aid of a physical model. The two lipids are miscible at the surface, but there is no indication of a specific interaction. In equimolar mixed monolayers at 25 and 37 degrees, the lipids are in tail contact. Lecithin molecules are able to remain hydrated in the mixed monolayers at high values of surface pressure.
摘要
借助物理模型研究了二棕榈酰卵磷脂和胆固醇在混合单分子层中的分子排列。这两种脂质在表面是可混溶的，但没有特定相互作用的迹象。在25℃和37℃的等摩尔混合单分子层中，脂质处于尾部接触状态。在高表面压力值下，卵磷脂分子能够在混合单分子层中保持水合状态。
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