β2-糖蛋白I与乙型肝炎病毒表面抗原之间的关系
[Relation between Beta-2-glycoprotein I and hepatitis B virus surface antigen].
作者信息
Gao Pujun, Guo Yanjun, Qu Like, Shi Tong, Zhang Hongyan, Dong Chun'e, Yang Hanyi
机构信息
Department of Internal Medicine, the First Affiliated Hospital, Norman Bethune University of Medical Sciences, Changchun 130021, China.
出版信息
Zhonghua Gan Zang Bing Za Zhi. 2002 Feb;10(1):31-3.
OBJECTIVE
To clarify the binding character between Beta-2-glycoprotein I (Beta-2-GPI) and HBsAg.
METHODS
Beta-2-GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg.
RESULTS
Biotinylated Beta-2-GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelled Beta-2-GPI.
CONCLUSIONS
Beta-2-GPI may play a role in hepatitis B virus infection.
目的
阐明β2-糖蛋白I（β2-GPI）与乙肝表面抗原（HBsAg）之间的结合特性。
方法
从人血浆中纯化β2-GPI并用生物素进行标记。采用固相酶联吸光测定法研究其与HBsAg的结合情况。
结果
发现生物素化的β2-GPI能与HBsAg结合，且该反应可被过量未标记的β2-GPI抑制。
结论
β2-GPI可能在乙型肝炎病毒感染中发挥作用。
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