Pério A, Barnouin M C, Poncelet M, Soubrié P
Centre de Recherche Sanofi-Synthélabo, Montpellier, France.
Behav Pharmacol. 2001 Dec;12(8):641-5. doi: 10.1097/00008877-200112000-00009.
Cannabinoids increase food intake, via CB1 receptors. The CB1 antagonist, SR141716, has been reported to decrease palatable food consumption in both operant and non-operant procedures. Similarly, CB1 receptor blockade diminished responding for normal food pellets under a fixed-ratio 15 (FR-15) schedule of reinforcement. The present experiment investigated whether the control of a continuous schedule of reinforcement (CRF) for sucrose pellets would be sensitive to the CB1 antagonist in mildly deprived rats. SR141716 dose-dependently reduced responding in a CRF procedure, by increasing post-reinforcement pauses. Together with formerly published conclusions, the data suggest that CB1 blockade reduces the rewarding efficacy of both palatable and non-palatable food.
大麻素通过CB1受体增加食物摄入量。据报道，CB1拮抗剂SR141716在操作性和非操作性程序中均可减少美味食物的摄入量。同样，在固定比例15（FR-15）强化程序下，CB1受体阻断减少了对正常食物颗粒的反应。本实验研究了在轻度饥饿的大鼠中，对蔗糖颗粒连续强化程序（CRF）的控制是否对CB1拮抗剂敏感。SR141716在CRF程序中通过增加强化后停顿，剂量依赖性地减少反应。与先前发表的结论一致，数据表明CB1阻断降低了美味和非美味食物的奖赏效力。
