接受雌二醇和孕酮替代治疗的极早产儿的钙磷平衡

Calcium and phosphorus balance of extremely preterm infants with estradiol and progesterone replacement.

作者信息

Trotter Andreas, Maier Ludwig, Pohlandt Frank

机构信息

Section of Neonatology and Pediatric Critical Care Medicine, Children's Hospital, Ulm, Germany.

出版信息

Am J Perinatol. 2002 Jan;19(1):23-9. doi: 10.1055/s-2002-20171.

DOI:10.1055/s-2002-20171

PMID:11857093

Abstract

Infants born extremely prematurely are deprived of the placental supply of estradiol (E2) and progesterone (Prog) at an earlier developmental stage compared to an infant born at term. We hypothesized that the retention of Ca (calcium) and P (phosphorus) would be improved by an E2 and Prog replacement. Twenty female infants with a mean gestational age of 26.6 weeks (+/-1.5 SD) and a mean birth weight of 744 g (+/-156) were enrolled in a randomized controlled pilot study. One group received an E2 and Prog replacement to maintain intrauterine plasma concentrations of E2 and Prog and the other group served as control. When intake of formula was at least 100 mL/kg/d, a 3-day Ca and P balance study was performed. Ca and P intake was increased individually until both elements were excreted in the urine. The mean Ca and P retention was 4.21 (+/-1.75) mMol/kg/d (58% of intake) and 2.66 (+/-1.01) mMol/kg/d (80%) in the replaced group and 3.39 (+/-1.69) mMol/kg/d (56%) and 2.03 (+/-0.79) mMol/kg/d (71%) in the control group, respectively. In this pilot study the retention of Ca and P was not improved by an E2 and Prog replacement.

摘要

与足月儿相比，极早产儿在更早的发育阶段就被剥夺了胎盘提供的雌二醇（E2）和孕酮（Prog）。我们假设，通过补充E2和Prog可以改善钙（Ca）和磷（P）的潴留情况。20名平均胎龄为26.6周（±1.5标准差）、平均出生体重为744克（±156）的女婴被纳入一项随机对照试验研究。一组接受E2和Prog补充以维持子宫内E2和Prog的血浆浓度，另一组作为对照组。当配方奶摄入量至少达到100 mL/kg/d时，进行为期3天的钙和磷平衡研究。分别增加钙和磷的摄入量，直到两种元素都通过尿液排出。补充组的平均钙和磷潴留量分别为4.21（±1.75）mmol/kg/d（占摄入量的58%）和2.66（±1.01）mmol/kg/d（80%），对照组分别为3.39（±1.69）mmol/kg/d（56%）和2.03（±0.79）mmol/kg/d（71%）。在这项试验研究中，补充E2和Prog并未改善钙和磷的潴留情况。