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激素疗法与乳腺癌

Hormone therapy and breast cancer.

作者信息

Zimmerman V L, Smeltzer S C

机构信息

Health Promotion for Women with Disabilities Project, College of Nursing, Villanova University, Pennsylvania 19085, USA.

出版信息

Clin Excell Nurse Pract. 2000 Jan;4(1):30-4.

Abstract

Use or nonuse of hormone therapy (HT) is a controversial decision for menopausal women that has taken on increasing significance as the large number of baby boomers enter this life stage. Studies suggest benefits of HT for prevention of osteoporosis and coronary artery disease, as well as a possible increased risk for cancer, particularly breast cancer. Because of this risk for breast cancer, women with a family history may feel differently about HT. However, differences have not been studied. The purpose of this study was to examine differences in attitudes toward HT of menopausal women with and without a family history of breast cancer. A nonexperimental, cross-sectional design was used. The setting included various sites located in a rural community in northwestern Pennsylvania. A convenience sample of 110 was obtained. A Health Belief Model attitudinal scale was completed by the participants. Although there were no significant differences in attitudes toward HT between the groups, ancillary analysis revealed a significant difference (P = .04) in frequency of reported fear of breast cancer regarding HT in those women with a family history of breast cancer and those without such a history. The findings of this study point to a need for further research on attitudes of women regarding HT and how they may affect postmenopausal healthcare management.

摘要

对于处于更年期的女性而言,使用或不使用激素疗法(HT)是一个颇具争议的决定。随着大量婴儿潮一代步入这一人生阶段,该决定的重要性日益凸显。研究表明,激素疗法有助于预防骨质疏松症和冠状动脉疾病,但同时也可能增加患癌风险,尤其是乳腺癌。鉴于存在患乳腺癌的风险,有家族病史的女性对激素疗法的看法可能会有所不同。然而,尚未对这种差异展开研究。本研究的目的在于探究有乳腺癌家族病史和没有乳腺癌家族病史的更年期女性在激素疗法态度上的差异。采用了非实验性横断面设计。研究地点包括宾夕法尼亚州西北部一个农村社区的多个场所。选取了110名方便样本。参与者完成了一份健康信念模型态度量表。尽管两组在激素疗法态度上没有显著差异,但辅助分析显示,有乳腺癌家族病史的女性和没有此类病史的女性在报告因激素疗法而担心患乳腺癌的频率上存在显著差异(P = 0.04)。本研究结果表明,有必要进一步研究女性对激素疗法的态度以及这些态度可能如何影响绝经后医疗保健管理。

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