来自黎巴嫩香科科亚种的新克罗烷二萜类化合物及其绝对构型。

Neoclerodane diterpenoids from Teucrium montbretii subsp. libanoticum and their absolute configuration.

作者信息

Bruno Maurizio, Bondì Maria Luisa, Rosselli Sergio, Maggio Antonella, Piozzi Franco, Arnold Nelly A

机构信息

Dipartimento Chimica Organica, Università Palermo, Viale delle Scienze, Parco d'Orleans II, 90128 Palermo, Italy.

出版信息

J Nat Prod. 2002 Feb;65(2):142-6. doi: 10.1021/np010303m.

DOI:10.1021/np010303m

PMID:11858745

Abstract

From the aerial parts of Teucrium montbretii subsp. libanoticum 10 neoclerodane diterpenoids were isolated. Three of them are new [3beta-hydroxyteubutilin A (1), 12-epi-montanin G (2), 20-epi-3,20-di-O-deacetylteupyreinidin (3)], whereas the other seven, namely, 6-ketoteuscordin (4), teuscordinon (5), 6beta-hydroxyteuscordin (6), montanin D (7), 3,20-di-O-deacetylteupyreinidin (8), montanin G (9), and 3-O-deacetylteugracilin A (10), are previously known structures. The structures of 1-3 were determined by spectral and chemical methods.

摘要

从黎巴嫩香科科（Teucrium montbretii subsp. libanoticum）的地上部分分离出10种新克罗烷二萜类化合物。其中3种是新化合物[3β-羟基特布替林A（1）、12-表-蒙塔宁G（2）、20-表-3,20-二-O-脱乙酰基特皮瑞尼定（3）]，而另外7种，即6-酮基特斯科丁（4）、特斯科迪农（5）、6β-羟基特斯科丁（6）、蒙塔宁D（7）、3,20-二-O-脱乙酰基特皮瑞尼定（8）、蒙塔宁G（9）和3-O-脱乙酰基特格拉西林A（10），是已知结构。通过光谱和化学方法确定了1-3的结构。