Wu Q, Wang X, Luo X
Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, P. R. China.
Zhonghua Shao Shang Za Zhi. 2001 Dec;17(6):354-6.
To explore the characteristics of the dynamic change in postburn erythrocyte membrane viscoelasticity and its influence on the regional myocardial blood flow.
Wistar rats inflicted with 30% TBSA III degree scalding on the back were employed as the model. The mechanical indices of erythrocytic membrane, such as elastic modulus and the coefficient of viscosity, were determined with micro-pipe sucking methods at preburn and 1, 3, 6, 12, 24 and 48 postburn hours (PBHs). The regional myocardial blood flow was simultaneously monitored with hydrogen clearance methods.
The erythrocyte membrane viscoelasticity increased sharply at 3 PBH, reached the peak level at 6 PBH and decreased gradually thereafter to near normal level at 24 PBH. The regional myocardial blood flow decreased obviously at 1 PBH, it reached the lowest level at 6 PBH and bounced back to near normal level at 48 PBHs. The change in the viscoelasticity was significantly and negatively correlated to that of the regional myocardial blood flow.
The deformability of postburn erythrocyte membrane decreased, leading to the decrease in the regional myocardial blood flow. This might be one of the important reasons of postburn myocardial injury.
探讨烧伤后红细胞膜黏弹性动态变化特点及其对局部心肌血流量的影响。
采用背部30%TBSAⅢ度烫伤的Wistar大鼠作为模型。于烧伤前及烧伤后1、3、6、12、24和48小时（PBH），用微管吸吮法测定红细胞膜的力学指标，如弹性模量和黏度系数。同时用氢清除法监测局部心肌血流量。
烧伤后3小时红细胞膜黏弹性急剧增加，6小时达到峰值水平，此后逐渐下降，至24小时恢复至接近正常水平。局部心肌血流量在烧伤后1小时明显下降，6小时降至最低水平，48小时反弹至接近正常水平。黏弹性变化与局部心肌血流量变化呈显著负相关。
烧伤后红细胞膜变形能力下降，导致局部心肌血流量减少。这可能是烧伤后心肌损伤的重要原因之一。
