Quéméneur T, Lambert M, Fauchais A L, Queyrel V, Michon-Pasturel U, Hachulla E, Hatron P Y, Devulder B
Service de médecine interne, hôpital Claude-Huriez, CHRU, rue Polonovski, 59037 Lille, France.
Rev Med Interne. 2002 Jan;23(1):77-80. doi: 10.1016/s0248-8663(01)00516-1.
Henoch-Schoenlein purpura has been reported to be associated with parvovirus B19 infection, particularly in children and rarely in adults. We report the case of a 42-year-old patient presenting with this association.
A 42-year-old patient was admitted to our medical center because of lower limb purpura. Henoch-Schoenlein purpura diagnosis was confirmed on histological findings (kidney biopsy) and concomitantly parvovirus B19 infection was proved by serological test (IgM+). Association of Henoch-Schoenlein purpura and parvovirus B19 infection has already been described. However, none of the reported studies demonstrated clearly the link between these two diseases. With regard to this observation, we wonder about the systematic use of the parvovirus B19 serological test in patients presenting first Henoch-Schoenlein purpura. Indeed, parvovirus B19-induced vasculitis is habitually controlled with intravenous immunoglobulins.
A prospective study should explore the link between Henoch-Schoenlein purpura and primary parvovirus B19 infection. Moreover, we should evaluate intravenous immunoglobulins' efficacy in Henoch-Schoenlein purpura associated with active parvovirus B19 infection in order to improve the prognosis of this disease.
据报道，过敏性紫癜与细小病毒B19感染有关，尤其是在儿童中，在成人中则很少见。我们报告了一例出现这种关联的42岁患者的病例。
一名42岁患者因下肢紫癜入住我们的医疗中心。根据组织学检查结果（肾脏活检）确诊为过敏性紫癜，同时血清学检测（IgM阳性）证实存在细小病毒B19感染。过敏性紫癜与细小病毒B19感染的关联已有报道。然而，所报道的研究均未明确证实这两种疾病之间的联系。关于这一观察结果，我们质疑对于首次出现过敏性紫癜的患者是否应常规进行细小病毒B19血清学检测。事实上，细小病毒B19引起的血管炎通常用静脉注射免疫球蛋白进行控制。
一项前瞻性研究应探索过敏性紫癜与原发性细小病毒B19感染之间的联系。此外，我们应评估静脉注射免疫球蛋白在与活动性细小病毒B19感染相关的过敏性紫癜中的疗效，以改善这种疾病的预后。
