[法国西部尿路结石的流行病学研究]

Decoster M, Bigot J C, Carre J L, Morin J F, Mahé J L, Tanquerel T, Cledes J, Floch H H

Laboratoire de Biochimie et Biologie Moléculaire, Centre Hospitalier Universitaire de la Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest.

Presse Med. 2002 Jan 26;31(3):113-8.

OBJECTIVES

An epidemiologic study of urinary calculi (N = 1843) was conducted in Western France: distribution according to the main chemical compounds, age and sex. Comparison with the results of a study with national recruitment (N = 10,617) and a study with regional recruitment (N = 1774).

METHOD

The study involved 1843 stones characterized beforehand by morphological analysis associated with infra-red spectrophotometry (FTIR). If analysis of the composition of the stones was carried out on the totality of calculi, studies related to age and sex included only 1583 cases. Comparison of percentages was made using chi 2 test.

RESULTS

The composition in main compounds of calculi was comparable with the results of other studies; minor significant compounds presented great differences, raising the problem of interpretation of the infra-red spectra of the latter. Hence, our work was directed towards the analysis of the major compounds and we showed, like most authors, that monohydrate calcium oxalate is predominant in male (46%) as well as in females (37%). Calculi average sex-ratio was 2.19 but dehydrated calcium oxalate sex-ratio was 4.42, suggesting that this compound is found mainly in men. Conversely, for the majority of phosphate stones, the sex-ratio was lower or equal to one, indicating that they predominate in women. Infectious calculi (particularly struvite calculi) appeared slightly more frequent in our population than in other studies, whereas the number of uric acid calculi was lower. This, however, remains to be confirmed.

CONCLUSION

The population studied was not significantly different from the national population regarding lithiasis, except perhaps for uric acid and struvite calculi, despite specific regional differences in diet and the role of nutritional factors in lithogenesis.

目的

在法国西部开展了一项关于尿路结石（N = 1843）的流行病学研究：根据主要化学成分、年龄和性别进行分布。与全国招募研究（N = 10,617）和区域招募研究（N = 1774）的结果进行比较。

方法

该研究涉及1843颗结石，这些结石事先通过与红外分光光度法（傅里叶变换红外光谱法）相关的形态分析进行了表征。如果对所有结石进行结石成分分析，与年龄和性别相关的研究仅包括1583例。使用卡方检验对百分比进行比较。

结果

结石主要化合物的组成与其他研究结果相当；次要的显著化合物存在很大差异，这引发了对后者红外光谱解释的问题。因此，我们的工作针对主要化合物的分析，并且我们和大多数作者一样表明，草酸钙一水合物在男性（46%）和女性（37%）中均占主导地位。结石的平均性别比为2.19，但草酸钙二水合物的性别比为4.42，这表明该化合物主要在男性中发现。相反，对于大多数磷酸盐结石，性别比低于或等于1，表明它们在女性中占主导地位。感染性结石（特别是磷酸镁铵结石）在我们的研究人群中似乎比其他研究中更常见，而尿酸结石的数量较少。然而，这仍有待证实。