Rostgaard K, Mouridsen H T, Vaeth M, Holst H, Olesen K P, Lynge E
University of Copenhagen, Denmark.
Acta Oncol. 2001;40(7):838-43. doi: 10.1080/02841860152703463.
Stage of disease at diagnosis is a predictor of breast cancer survival. We used data from the Danish Cancer Register and the Danish Breast Cancer Cooperative Group to study stage distribution in 0-69-year-old Danish breast cancer patients diagnosed in 1978-1994. We constructed a modified Nottingham Prognostic Index (NPI) calculated from the number of excised and positive lymph nodes, malignancy grade and tumour diameter. This NPI could be calculated for 63% of the patients, and among these the stage distribution improved during the study period. The proportion of patients with a poor prognostic score decreased from 27% to 20%. Based on a comparison of the crude 3-year survival of patients with an NPI score and those without, it seems probable that the stage of disease at diagnosis on average improved in Danish breast cancer patients below age 70 during the 1980s and the early 1990s.
确诊时的疾病分期是乳腺癌生存情况的一个预测指标。我们利用丹麦癌症登记处和丹麦乳腺癌协作组的数据，研究了1978年至1994年确诊的0至69岁丹麦乳腺癌患者的分期分布情况。我们构建了一个改良的诺丁汉预后指数（NPI），该指数由切除的和阳性淋巴结数量、恶性肿瘤分级以及肿瘤直径计算得出。63%的患者能够计算出这个NPI，在这些患者中，研究期间分期分布有所改善。预后评分差的患者比例从27%降至20%。基于对有NPI评分患者和无NPI评分患者的粗略3年生存率比较，在20世纪80年代和90年代初，丹麦70岁以下乳腺癌患者确诊时的疾病分期平均似乎有所改善。
