Chadwick M A, Buckland J R, Mason P, Randall C J, Theaker J
Department of Otolaryngology, Southampton University Hospitals NHS Trust, Southampton, UK.
J Laryngol Otol. 2002 Jan;116(1):54-6. doi: 10.1258/0022215021910140.
Amyloidoses are a group of disorders in which deposition of abnormal amounts of protein complexes (amyloid) occurs in a variety of tissues. The upper aerodigestive tract may be affected, particularly the larynx, but hypopharyngeal involvement is rarely reported. We present a unique case of amyloidosis of the post-cricoid region causing dysphagia. This case report highlights the need for otolaryngologists to consider the possibility of submucosal amyloid deposition, in the absence of mucosal lesions, in patients who present with dysphagia secondary to an obstructive lesion of the post cricoid region.
淀粉样变性是一组疾病，其中异常量的蛋白质复合物（淀粉样蛋白）沉积在多种组织中。上呼吸道和消化道可能会受到影响，尤其是喉部，但下咽受累的情况很少被报道。我们报告一例环状软骨后区域淀粉样变性导致吞咽困难的独特病例。本病例报告强调，对于因环状软骨后区域阻塞性病变继发吞咽困难的患者，在没有黏膜病变的情况下，耳鼻喉科医生有必要考虑黏膜下淀粉样蛋白沉积的可能性。
