Chen Zhong, Shen Ying-Jie
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China.
Acta Pharmacol Sin. 2002 Jan;23(1):66-70.
To investigate whether or not brain histamine was involved in memory deficits induced by lesions of nucleus basalis magnocellularis (NBM) in rats.
Passive avoidance response was used to measure memory process in rats, and NBM was bilaterally lesioned by injection of ibotenic acid (6 microg/site).
Icv injection of histamine (500 ng), and ip injection of histidine (1500 mg/kg), metoprine (10 mg/kg) or tacrine (3, 5 mg/kg) ameliorated memory impairment induced by NBM lesion regarding passive avoidance response. The ameliorating effect of histidine was antagonized by pyrilamine (2-5 mg/kg), a H1-antagonist, but not by zolantidine, a H2-antagonist.
Histaminergic neurons play an important role in learning and memory via H1-receptor, and its action may be due to cholinergic neurons.
研究脑内组胺是否参与大鼠基底大细胞核（NBM）损伤所致的记忆缺陷。
采用被动回避反应来测量大鼠的记忆过程，通过注射鹅膏蕈氨酸（6微克/位点）对双侧NBM进行损伤。
脑室内注射组胺（500纳克）、腹腔注射组氨酸（1500毫克/千克）、美托普令（10毫克/千克）或他克林（3、5毫克/千克）可改善NBM损伤所致的被动回避反应记忆障碍。组氨酸的改善作用被H1拮抗剂吡苄明（2 - 5毫克/千克）拮抗，但未被H2拮抗剂佐兰丁拮抗。
组胺能神经元通过H1受体在学习和记忆中起重要作用，其作用可能与胆碱能神经元有关。
