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[2型糖尿病患者并发脑梗死危险因素的研究]

[A study on the risk factors of cerebral infarction as complication of type 2 diabetes mellitu patients].

作者信息

Meng Q, Wang J, Wang Z

机构信息

Tianjin Medical University, School of Public Health, Tianjin 300070, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2001 Jun;22(3):208-11.

Abstract

OBJECTIVE

Cerebral infarction, a common acute cereovascular disease, is one of the main complications of type 2 diabetes mellitus (DM). This paper is to explore the risk factors of cerebral infarction among type 2 DM patients.

METHODS

A pair-matched case-control study was carried out. Data was analyzed with conditional logistic regression.

RESULTS

One hundred and ten type 2 DM patients with cerebral infarction and controls were selected respectively. Results showed that higher educational level and physical exercises lowered the risk of cerebral infarction among type 2 DM patients. Higher HDL-C and blood sugar under control could also lower the risk of developing cerebral infarction among type 2 DM patients. The above factors seemed to have protective functions. Excessive salt intake and snoring increased the risks of cerebral infarction development among type 2 DM patients. Hypertension served as an independent risk factor while atrial fibrillation and hyperinsulinemia were important risk factors. High LDL-C, Apo-A, Lp(a), Fg increased the risk of cerebral infarction among type 2 DM patients. The study did not discover the relationship of smoking, drinking, oral contraception, menstrual and obstetrical history, TC, TG, Apo-A and cerebral infarction among type 2 DM patients.

CONCLUSION

To prevent cerebral infarction among type 2 DM, measures need to be taken as control of salt intake; eating more vegetables; regular physical exercises; control of blood sugar, blood pressure and Hyperinsulinemia.

摘要

目的

脑梗死是常见的急性脑血管疾病,是2型糖尿病(DM)的主要并发症之一。本文旨在探讨2型糖尿病患者脑梗死的危险因素。

方法

开展配对病例对照研究。采用条件逻辑回归分析数据。

结果

分别选取110例2型糖尿病合并脑梗死患者及对照。结果显示,较高的教育水平和体育锻炼可降低2型糖尿病患者脑梗死风险。较高的高密度脂蛋白胆固醇(HDL-C)水平及血糖得到控制也可降低2型糖尿病患者发生脑梗死的风险。上述因素似乎具有保护作用。过量盐摄入及打鼾会增加2型糖尿病患者发生脑梗死的风险。高血压是独立危险因素,而心房颤动和高胰岛素血症是重要危险因素。高低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(Apo-A)、脂蛋白(a)[Lp(a)]、纤维蛋白原(Fg)增加2型糖尿病患者脑梗死风险。该研究未发现2型糖尿病患者吸烟、饮酒、口服避孕药、月经及产科病史、总胆固醇(TC)、甘油三酯(TG)、载脂蛋白A与脑梗死之间的关系。

结论

为预防2型糖尿病患者发生脑梗死,需采取控制盐摄入、多吃蔬菜、定期体育锻炼、控制血糖、血压及高胰岛素血症等措施。

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