基因对人类认知的影响：来自智力发育迟缓综合征研究的启示。
Genetic effects on human cognition: lessons from the study of mental retardation syndromes.
作者信息
Nokelainen P, Flint J
机构信息
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
出版信息
J Neurol Neurosurg Psychiatry. 2002 Mar;72(3):287-96. doi: 10.1136/jnnp.72.3.287.
Abstract
The molecular basis of human cognition is still poorly understood, but recent advances in finding genetic mutations that result in cognitive impairment may provide insights into the neurobiology of cognitive function. Here we review the progress that has been made so far and assess what has been learnt from this work on the relation between genes and cognitive processes. We review evidence that the pathway from genetic lesion to cognitive impairment can be dissected, that some genetic effects on cognition are relatively direct and we argue that the study of mental retardation syndromes is giving us new clues about the biological bases of cognition.
摘要
人类认知的分子基础仍知之甚少，但在寻找导致认知障碍的基因突变方面的最新进展可能为认知功能的神经生物学提供见解。在这里，我们回顾了迄今为止所取得的进展，并评估了从这项关于基因与认知过程关系的研究中学到了什么。我们回顾了相关证据，即从基因损伤到认知障碍的途径可以被剖析，一些对认知的基因影响相对直接，并且我们认为对智力迟钝综合征的研究正在为我们提供有关认知生物学基础的新线索。
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