[一氧化氮与青光眼眼压升高关系的临床研究]

[A clinical investigation on the relationship between nitric oxide and elevation of intraocular pressure in glaucoma].

作者信息

Han Y, Zhang B, Guo X, Zhang Z

机构信息

Department of Ophthalmology, Affiliated Second Hospital, Hebei Medical University, Shijiazhuang 050000, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2001 Jul;37(4):281-3.

PMID:11864438

Abstract

OBJECTIVE

To investigate the role of nitric oxide (NO) in the process of intraocular pressure (IOP) elevation in glaucoma.

METHODS

The levels of NO in plasma and in aqueous humor which were obtained from 16 patients with acute angle closure glaucoma (10 female, 6 male), 29 cases with cataract (13 female, 16 male) and 30 normal volunteers (13 female, 17 male) were detected by high performance liquid chromatography and expressed with the total NO(2) and NO(3).

RESULTS

It was found that the mean level of NO in the plasma in glaucoma group was (l,390.78 +/- 302.95) ng/L that was significantly lower than that in the normal group (2 969.37 +/- 862.85) ng/L (t = 2.853, P < 0.01). But in cataract group it was (4,234.89 +/- 1,495.23) ng/L that was significantly higher than that in the normal group (t = 4.471, P < 0.01). There was no significant difference in the level of NO in the aqueous humor between glaucoma group (2,052.03 +/- 694.74) ng/L and normal group (1,405.83 +/- 602.70) ng/L (t = l.862, P > 0.05). But in cataract group the mean level of NO (2, 454.67 +/- 655.13) ng/L in the aqueous humor was increased remarkably in comparison with that in the normal group (t = 2.752, P < 0.01). The rate of the mean content of NO in normal aqueous humor and plasma (aqueous/plasma) was 47.3%, and that in cataract group, 57.96% (P > 0.05). But in glaucoma group, the rate was 144.0%.

CONCLUSION

The content of nitric oxide in the plasma and aqueous humor is related to the elevation of IOP in cases with acute angle closure glaucoma.

摘要

目的

探讨一氧化氮（NO）在青光眼眼压（IOP）升高过程中的作用。

方法

采用高效液相色谱法检测16例急性闭角型青光眼患者（女性10例，男性6例）、29例白内障患者（女性13例，男性16例）及30例正常志愿者（女性13例，男性17例）血浆和房水中NO的水平，以总NO₂和NO₃表示。

结果

发现青光眼组血浆中NO的平均水平为（1390.78±302.95）ng/L，显著低于正常组（2969.37±862.85）ng/L（t = 2.853，P < 0.01）。而白内障组为（4234.89±1495.23）ng/L，显著高于正常组（t = 4.471，P < 0.01）。青光眼组房水中NO水平（2052.03±694.74）ng/L与正常组（1405.83±602.70）ng/L相比差异无统计学意义（t = 1.862，P > 0.05）。但白内障组房水中NO平均水平（2454.67±655.13）ng/L与正常组相比显著升高（t = 2.752，P < 0.01）。正常房水与血浆中NO平均含量的比值（房水/血浆）为47.3%，白内障组为57.96%（P > 0.05）。但青光眼组该比值为144.0%。