青光眼眼中房水中的红细胞生成素增加。

Erythropoietin is increased in aqueous humor of glaucomatous eyes.

机构信息

Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

出版信息

Curr Eye Res. 2010 Aug;35(8):680-4. doi: 10.3109/02713681003778780.

DOI:10.3109/02713681003778780

PMID:20673044

Abstract

PURPOSE

To determine the aqueous concentration of erythropoietin (EPO) in patients with and without glaucoma.

METHODS

Prospective, comparative control study. Concentrations of EPO in the aqueous humor were measured using ELISA kits from 75 patients, of whom 55 had glaucoma (14 primary acute angle-closure glaucoma, PAACG; 26 primary chronic angle-closure glaucoma, PCACG; 11 primary open-angle glaucoma, POAG; 4 neovascular glaucoma, NVG), and 20 had cataract only as control.

RESULTS

EPO concentrations in eyes with glaucoma (71.0 +/- 12.0 mU/mL) were significantly higher than those in eyes with cataract (6.4 +/- 0.8 mU/mL, P < 0.001). There were no significant differences (P = 0.421) between PCACG (28.84 +/- 3.9 mU/mL) and POAG (20.2 +/- 2.0 mU/mL); however, EPO concentrations in eyes with PAACG (118.5 +/- 14 mU/mL) were significantly higher than these two chronic subtypes of glaucoma (P < 0.001, respectively). Unusually high EPO concentrations were detected in four eyes with NVG (319.5 +/- 47.7 mU/mL). No effect of age, gender, different eyes, body mass index of the aqueous humor EPO concentration could be detected (P > 0.05). No significant correlation was found between aqueous humor and plasma EPO concentrations in PAACG and control group (P = 0.285, 0.500, respectively).

CONCLUSION

Our prospective study suggests that the aqueous humor EPO concentrations are increased in eyes with glaucoma.

摘要

目的

确定青光眼患者和非青光眼患者房水中促红细胞生成素 (EPO) 的浓度。

方法

前瞻性对照研究。使用 ELISA 试剂盒测量 75 例患者房水中的 EPO 浓度，其中 55 例患有青光眼（14 例原发性急性闭角型青光眼，PAACG；26 例原发性慢性闭角型青光眼，PCACG；11 例原发性开角型青光眼，POAG；4 例新生血管性青光眼，NVG），20 例仅患有白内障作为对照。

结果

青光眼眼房水中的 EPO 浓度（71.0±12.0 mU/mL）明显高于白内障眼房水中的 EPO 浓度（6.4±0.8 mU/mL，P<0.001）。PCACG（28.84±3.9 mU/mL）和 POAG（20.2±2.0 mU/mL）之间差异无统计学意义（P=0.421）；然而，PAACG 眼中的 EPO 浓度（118.5±14 mU/mL）明显高于这两种慢性青光眼亚型（P<0.001）。4 例 NVG 眼中检测到异常高的 EPO 浓度（319.5±47.7 mU/mL）。未检测到年龄、性别、不同眼、房水中的体质量指数对 EPO 浓度的影响（P>0.05）。PAACG 和对照组房水和血浆 EPO 浓度之间未发现显著相关性（P=0.285，0.500）。