Chesley L C
Obstet Gynecol. 1975 Dec;46(6):699-705.
All but 3 of 263 women with confirmed rheumatic cardiac disease seen during pregnancy in the 5-year period, July 1937 to August 1942, have been traced up to 1974. The series was enlarged by including all the cases (57) in functional Classes III and IV at conception which were seen from 1931 through 1943; all have been traced. The remote mortalities have been: in patients Class I at conception, 58.3% dead (with an average annual death rate of 23.5/1000); Class II at conception, 73.8% dead (average annual death rate 36.5/1000); Classes III and IV at conception, 91.3% dead (average annual death rate, 66.5/1000). A comparison of women with and without pregnancies subsequent to the one admitting them to the study fails to show any remote adverse effect of later pregnancies of the course of the disease.
在1937年7月至1942年8月这5年期间，对孕期确诊患有风湿性心脏病的263名女性进行追踪，截至1974年，其中除3人外均已找到。通过纳入1931年至1943年期间受孕时心功能为Ⅲ级和Ⅳ级的所有病例（57例），扩大了该系列研究范围；所有病例均已找到。远期死亡率如下：受孕时心功能Ⅰ级的患者，58.3%死亡（年均死亡率为23.5/1000）；受孕时心功能Ⅱ级的患者，73.8%死亡（年均死亡率为36.5/1000）；受孕时心功能Ⅲ级和Ⅳ级的患者，91.3%死亡（年均死亡率为66.5/1000）。对纳入研究时已怀孕的女性与未怀孕的女性进行比较，未发现后续怀孕对疾病进程有任何远期不良影响。
