Davis D R, Yeary R A
Pediatr Res. 1975 Nov;9(11):846-50. doi: 10.1203/00006450-197511000-00009.
Sulfadimethoxine significantly reduced plasma bilirubin levels and altered the tissue bilirubin distribution in both the newborn and the adult Gunn rat. The majority of the unbound bilirubin appeared to distribute perferentially to the intestine and liver in the newborn, whereas in the adult the unbound bilirubin was taken up primarily by the liver. The bilirubin content of brain tissue from both age groups was significantly higher after sulfadimethoxine treatment.
磺胺二甲氧嘧啶显著降低了新生和成年冈恩大鼠的血浆胆红素水平，并改变了组织胆红素分布。在新生大鼠中，大部分未结合胆红素似乎优先分布于肠道和肝脏，而在成年大鼠中，未结合胆红素主要被肝脏摄取。磺胺二甲氧嘧啶治疗后，两个年龄组的脑组织胆红素含量均显著升高。
