Rokita-Wala I, Gierek-Ciaciura S, Majlinger R, Wygledowska-Promieńska D
I Katedry i Kliniki Okulistyki Slaskiej AM w Katowicach.
Klin Oczna. 2001;103(2-3):111-5.
The study aimed to evaluate the iron deposits in corneas in confocal microscope.
The material comprised 16 eyes which underwent photorefractive keratectomy (PRK) procedure. The structure of corneas was evaluated between 3-10 years after PRK. The visual acuity after PRK was the same as the best corrected visual acuity before the procedure. The structure of corneas was evaluated in vivo using scanning slit confocal microscopy. The confocal images of corneas in patients after PRK were compared with confocal corneal images of patients with corneal scars (2 eyes), keratoconus (2 eyes), after radial keratotomy (RK) (2 eyes) and healthy patients.
Within the central part of corneal epithelium and anterior part of stroma, the clusters of iron deposits were observed. They were round and produced different shapes. In the paracentral and peripheral part of corneas the subepithelial nerve plexus was detected. Beneath, the pattern of keratocytic nuclei, characteristic for state after PRK, was detected. In patients with corneal scars, keratoconus and after RK, the same clusters of deposits were detected. In cases of corneal scars, additionally high reflectivity of corneal structure was observed.
The iron deposits in corneal structure arise in epithelium and anterior part of corneal stroma. The iron deposits which produce different shapes have no influence on visual acuity.
本研究旨在通过共聚焦显微镜评估角膜中的铁沉积情况。
材料包括16只接受了准分子激光原位角膜磨镶术(PRK)的眼睛。在PRK术后3至10年评估角膜结构。PRK术后的视力与手术前最佳矫正视力相同。使用扫描裂隙共聚焦显微镜在活体状态下评估角膜结构。将PRK术后患者的角膜共聚焦图像与角膜瘢痕患者(2只眼)、圆锥角膜患者(2只眼)、放射状角膜切开术(RK)后患者(2只眼)以及健康患者的角膜共聚焦图像进行比较。
在角膜上皮中央部分和基质前部观察到铁沉积簇。它们呈圆形且形状各异。在角膜旁中央和周边部分检测到上皮下神经丛。其下方检测到PRK术后状态特有的角膜细胞细胞核模式。在角膜瘢痕、圆锥角膜患者以及RK术后患者中检测到相同的沉积簇。在角膜瘢痕病例中,还观察到角膜结构的高反射率。
角膜结构中的铁沉积出现在角膜上皮和角膜基质前部。产生不同形状的铁沉积对视敏度没有影响。