Jacobi Johannes, Schneider Markus P, John Stefan, Schmieder Roland E
Department of Medicine/Nephrology, University of Erlangen-Nürnberg, Germany.
J Hypertens. 2002 Mar;20(3):525-30. doi: 10.1097/00004872-200203000-00029.
To examine the acute effects of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects.
Changes of renal plasma flow (RPF) and glomerular filtration rate (GFR) in response to intravenous infusions of NG-monomethyl-l-arginine (l-NMMA) (3 mg/kg per 30 min) were measured in 32 normotensive and in 39 essential hypertensive patients by use of clearance technique.
l-NMMA significantly decreased RPF in normotensive and hypertensive individuals (P < 0.001), while GFR was preserved. Changes of renal hemodynamic parameters were similar in hypertensive and normotensive subjects (deltaRPF: -88 +/- 89 versus -81 +/- 105 ml/min, P = NS; deltaGFR 1.6 +/- 8.2 versus 4.3 +/- 8.9 ml/min, P = NS) Furthermore, l-NMMA increased mean arterial pressure (deltaMAP 5.3 +/- 6.3 versus 6.0 +/- 6.1 mmHg, P = NS) and decreased heart rate (deltaHR -5.8 +/- 3.9 versus -4.1 +/- 3.8 beats/min, P = NS) to a similar extent in both groups.
Basal NO synthesis of the renal vasculature is not impaired in patients with established essential hypertension.
研究一氧化氮合酶抑制对正常血压和高血压受试者肾脏血流动力学的急性影响。
采用清除技术，在32名正常血压患者和39名原发性高血压患者中，测量静脉输注NG-单甲基-L-精氨酸（L-NMMA）（每30分钟3mg/kg）后肾血浆流量（RPF）和肾小球滤过率（GFR）的变化。
L-NMMA显著降低了正常血压和高血压个体的RPF（P<0.001），而GFR保持不变。高血压和正常血压受试者的肾脏血流动力学参数变化相似（ΔRPF：-88±89对-81±105ml/min，P=无显著性差异；ΔGFR 1.6±8.2对4.3±8.9ml/min，P=无显著性差异）。此外，L-NMMA使两组的平均动脉压升高（ΔMAP 5.3±6.3对6.0±6.1mmHg，P=无显著性差异），心率降低（ΔHR -5.8±3.9对-4.1±3.8次/分钟，P=无显著性差异）的程度相似。
原发性高血压患者肾脏血管的基础一氧化氮合成未受损。
