Golusin Z, Jovanović M, Poljacki M
Klinicki centar Novi Sad, Klinika za kozno-venericne bolesti, 21000 Novi Sad, Hajduk Veljkova 1-3.
Med Pregl. 2001 Sep-Oct;54(9-10):486-9.
Keratosis pilaris atrophicans faciei (KPAF), previously called ulerythema ophryogenes, belongs to a group of follicular syndromes with inflammation and atrophy. The disease often starts at birth or during the first months of life with autosomal dominant inheritance.
We report a case of a 24-year-old woman, who noticed the first lesion two years ago. Skin lesion spread symmetrically on the cheeks, forehead and chin. Keratotic follicular papules were surrounded by erythema. After disappearance of follicular papules, atrophy occurred. Histopathological analysis from skin biopsy specimens confirmed the diagnosis of KPAF.
Follicular syndrome with inflammation and atrophy starts in early childhood, but first lesions can also appear among teenagers or in adults. The course of the disease is progressive with permanent follicular destruction. The histopathologic changes are dynamic and follow the clinical course of the disease. A topical retinoid: tretinoin therapy was introduced. After one month of treatment good effects were visible, including decrease of erythema and follicular hyperkeratosis.
面部萎缩性毛发角化病（KPAF），以前称为眉部瘢痕性红斑，属于一组伴有炎症和萎缩的毛囊综合征。该病通常在出生时或出生后的头几个月开始，呈常染色体显性遗传。
我们报告一例24岁女性病例，她在两年前发现了首个皮损。皮损对称分布于脸颊、前额和下巴。角化性毛囊丘疹周围有红斑。毛囊丘疹消失后出现萎缩。皮肤活检标本的组织病理学分析证实了面部萎缩性毛发角化病的诊断。
伴有炎症和萎缩的毛囊综合征始于儿童早期，但首个皮损也可能出现在青少年或成年人中。疾病进程呈进行性，伴有永久性毛囊破坏。组织病理学变化是动态的，并与疾病的临床进程相关。采用了外用维甲酸：维甲酸治疗。治疗一个月后可见良好效果，包括红斑减轻和毛囊角化过度减轻。
