Shao Z, Shi J, Chen G, Li K, Liu H, Zhang Y, Zheng Y, He H, Zhao M, He G, Zhang H, Chu Y, Hao Y
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
Zhonghua Xue Ye Xue Za Zhi. 2000 Apr;21(4):182-6.
To explore prospective diagnostic criteria for preleukemia.
A case control study of the discrepancies of clinical and laboratory features between patients with preleukemia and those with chronic aplastic anemia (CAA) or atypical paroxysmal nocturnal hemoglubinuria (a-PNH).
There were eight variables of significance: (1) lymphocytoid micromegakaryocytes in marrow; (2) immature granulocytes in peripheral blood; (3) >or= 2% myeloblasts in marrow; (4) positive periodic acid schiff (PAS) staining of nucleated erythrocytes; (5) myeloid differentiation index >or= 1.8; (6) clonal karyotypic abnormalities; (7) negative sister chromatid differentiation; (8) > 4.0 cluster/colony ratio of granulocyte-macrophage colony-forming units (CFU-GM). The following criteria was assigned: A: To meet (1) and at least two of the other seven variables; B: To meet at least four of the eight variables. All of the patients with preleukemia met A or B and none of the patients with CAA or a-PNH did.
Preleukemia is different from CAA or a-PNH. It has its own clinical and laboratory features, which may be useful for prospective diagnosis.
探讨白血病前期的前瞻性诊断标准。
采用病例对照研究方法，比较白血病前期患者与慢性再生障碍性贫血（CAA）或非典型阵发性睡眠性血红蛋白尿（a-PNH）患者临床及实验室特征的差异。
有8个具有显著意义的变量：（1）骨髓中淋巴细胞样小巨核细胞；（2）外周血中未成熟粒细胞；（3）骨髓中原始粒细胞≥2%；（4）有核红细胞糖原染色（PAS）阳性；（5）髓系分化指数≥1.8；（6）克隆性核型异常；（7）姐妹染色单体分化阴性；（8）粒-巨噬细胞集落形成单位（CFU-GM）集簇/集落比值＞4.0。制定如下标准：A：符合（1）且符合其他7个变量中的至少2个；B：符合8个变量中的至少4个。所有白血病前期患者均符合A或B标准，而CAA或a-PNH患者均不符合。
白血病前期与CAA或a-PNH不同。它有自身的临床及实验室特征，这可能有助于前瞻性诊断。
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