Ahmed H M
Pharmazie. 1975 Sep;30(9):598-602.
Calcium chloride increased the liver insulinase activity (LIA) in normal rabbits. No significant changes were noted in the plasma insulinlike activity (PILA), serum zinc level (SZ), and pancreatic zinc content (PZ). Insulin elevated PILA, SZ and PZ but did not affect LIA. Calcium chloride enhanced the effect of insulin on PILA, SZ and PZ. However, insulin did not affect the action of calcium chloride on LIA. Tolbutamide raised PILA, inhibited both LIA and SZ but did not affect PZ. Calcium chloride produced no change in the action of tolbutamide on PILA. On the other hand, tolbutamide prevented the rise of PILA obtained by calcium chloride. PZ was unaltered with calcium chloride and tolbutamide combination. Phenformin increased PILA, LIA, SZ and PZ. When it was given with calcium chloride no further changes in PILA and PZ were observed. The elevation of SZ was abolished but the rise of LIA was synergized. In alloxanized rabbits, LIA was decreased by calcium chloride. No changes were found in PILA, SZ and PZ. Insulin elevated PILA, LIA and SZ although it reduced PZ. Calcium chloride stimulated insulin effect on PILA, did not affect its action on SZ or PZ, and antagonized its effect on LIA. Tolbutamide increased LIA and SZ but did not affect PILA or PZ. Calcium chloride could not change the effect of tolbutamide on SZ or PILA although it could abolish the action of this drug on LIA and PZ. Phenformin significantly lowered PILA, LIA and PZ but raised SZ. Calcium chloride combination with phenformin produced a further decrease in LIA but no other changes in PIAL, SZ or PZ were recorded.
氯化钙可提高正常家兔肝脏胰岛素酶活性（LIA）。血浆胰岛素样活性（PILA）、血清锌水平（SZ）和胰腺锌含量（PZ）未见明显变化。胰岛素可升高PILA、SZ和PZ，但不影响LIA。氯化钙可增强胰岛素对PILA、SZ和PZ的作用。然而，胰岛素不影响氯化钙对LIA的作用。甲苯磺丁脲可升高PILA，抑制LIA和SZ，但不影响PZ。氯化钙对甲苯磺丁脲作用于PILA无影响。另一方面，甲苯磺丁脲可阻止氯化钙引起的PILA升高。氯化钙与甲苯磺丁脲联合使用时，PZ未发生改变。苯乙双胍可升高PILA、LIA、SZ和PZ。当与氯化钙合用时，PILA和PZ未见进一步变化。SZ的升高被消除，但LIA的升高出现协同作用。在四氧嘧啶致糖尿病家兔中，氯化钙可降低LIA。PILA、SZ和PZ未见变化。胰岛素可升高PILA、LIA和SZ，尽管它降低了PZ。氯化钙可增强胰岛素对PILA的作用，不影响其对SZ或PZ的作用，并拮抗其对LIA的作用。甲苯磺丁脲可升高LIA和SZ，但不影响PILA或PZ。氯化钙不能改变甲苯磺丁脲对SZ或PILA的作用，尽管它可消除该药物对LIA和PZ的作用。苯乙双胍可显著降低PILA、LIA和PZ，但升高SZ。氯化钙与苯乙双胍联合使用可使LIA进一步降低，但PIAL、SZ或PZ未见其他变化。
