通过促进中枢儿茶酚胺能机制的药物逆转6-羟基多巴胺诱导的CAR抑制。
Reversal of the 6-hydroxydopamine-induced suppression of a CAR by drugs facilitating central catecholaminergic mechanisms.
作者信息
Ruiz M, Monti J M
出版信息
Pharmacology. 1975;13(4):281-6. doi: 10.1159/000136917.
PMID:1187753
Abstract
The intraventricular injection of 6-hydroxydopamine (200 mug) blocked a previously learned conditioned avoidance response (CAR) in rats. The administration of NE, DOPA, amphetamine, phenelzine, desipramine and clonidine induced the reappearance of the CAR. These results are in agreement with current hypotheses on the mechanism of action of 6-hydroxydopamine on the central nervous system.
摘要
脑室内注射6-羟基多巴胺（200微克）可阻断大鼠先前习得的条件性回避反应（CAR）。给予去甲肾上腺素、多巴、苯丙胺、苯乙肼、地昔帕明和可乐定可使条件性回避反应重新出现。这些结果与目前关于6-羟基多巴胺对中枢神经系统作用机制的假说一致。
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