富马酸2-（2,6-二氯苯基）-5,6-二氢咪唑并（2,1-b）噻唑（化合物44-549）引起的中枢性低血压

Centrally induced hypotension by 2-(2,6-dichlorophenyl)-5,6-dihydroimidazo (2,1-b)-thiazole fumarate (compound 44-549).

作者信息

van Zwieten P A

出版信息

Pharmacology. 1975;13(4):352-5. doi: 10.1159/000136924.

Abstract

The experimental compound 44-549 = 2-(2,6-dichlorophenyl)-5,6-dihydroimidazo (2,1-b)-thiazole fumarate was tested in chloralose-anaesthetized cats. Low doses of compound 44-549 showed a much more pronounced hypotensive effect when injected into the left vertebral artery than upon intravenous administration. The compound possesses central hypotensive activity, which could be blocked by yohimbine, administered via the vertebral artery. Central alpha-adrenoreceptors are probably involved. Compound 44-549 resembles clonidine both pharmacologically and chemically. It is somewhat less potent.

摘要

实验性化合物44 - 549（富马酸2 - (2,6 - 二氯苯基)-5,6 - 二氢咪唑并(2,1 - b)-噻唑）在氯醛糖麻醉的猫身上进行了测试。低剂量的化合物44 - 549经左椎动脉注射时，其降压作用比静脉给药时更为显著。该化合物具有中枢性降压活性，通过椎动脉给药的育亨宾可阻断此活性。可能涉及中枢α - 肾上腺素能受体。化合物44 - 549在药理和化学方面与可乐定相似。其效力稍弱。