恶性疟原虫对抗疟药物的耐药机制。

Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs.

作者信息

Hyde John E

机构信息

Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P.O. Box 88, M60 1QD, Manchester, UK.

出版信息

Microbes Infect. 2002 Feb;4(2):165-74. doi: 10.1016/s1286-4579(01)01524-6.

DOI:10.1016/s1286-4579(01)01524-6

PMID:11880048

Abstract

Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here.

摘要

化疗和化学预防是在人类宿主中对抗疟原虫感染的主要手段。在过去75年里，自合成抗疟药问世以来，仅发现少数几种化合物适合临床使用，而这一有限的药物库如今因耐药寄生虫菌株的传播而受到极大影响。本文综述了我们目前对致死性疟原虫恶性疟原虫耐药性潜在分子机制的认识。