原生动物寄生虫中的耐药性。
Drug resistance in protozoan parasites.
作者信息
de Koning Harry P
机构信息
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
出版信息
Emerg Top Life Sci. 2017 Dec 22;1(6):627-632. doi: 10.1042/ETLS20170113.
Abstract
As with all other anti-infectives (antibiotics, anti-viral drugs, and anthelminthics), the limited arsenal of anti-protozoal drugs is being depleted by a combination of two factors: increasing drug resistance and the failure to replace old and often shamefully inadequate drugs, including those compromised by (cross)-resistance, through the development of new anti-parasitics. Both factors are equally to blame: a leaking bathtub may have plenty of water if the tap is left open; if not, it will soon be empty. Here, I will reflect on the factors that contribute to the drug resistance emergency that is unfolding around us, specifically resistance in protozoan parasites.
摘要
与所有其他抗感染药物（抗生素、抗病毒药物和抗蠕虫药物）一样，抗寄生虫药物的有限储备正因两个因素的共同作用而逐渐枯竭：耐药性不断增加，以及未能通过开发新的抗寄生虫药物来替代旧的、往往严重不足的药物，包括那些因（交叉）耐药性而受损的药物。这两个因素都难辞其咎：如果水龙头开着，漏水的浴缸可能还有很多水；如果不开，很快就会空了。在此，我将思考导致我们周围正在出现的耐药性紧急情况的因素，特别是原生动物寄生虫的耐药性。
相似文献
1
Drug resistance in protozoan parasites.原生动物寄生虫中的耐药性。
Emerg Top Life Sci. 2017 Dec 22;1(6):627-632. doi: 10.1042/ETLS20170113.
2
Multiple Regulations of Parasitic Protozoan Viruses: A Double-Edged Sword for Protozoa.寄生虫原生动物病毒的多重调控：原生动物的双刃剑。
mBio. 2023 Feb 28;14(1):e0264222. doi: 10.1128/mbio.02642-22. Epub 2023 Jan 12.
3
New mechanisms of drug resistance in parasitic protozoa.寄生原生动物耐药性的新机制
Annu Rev Microbiol. 1995;49:427-60. doi: 10.1146/annurev.mi.49.100195.002235.
4
Mitochondrion of protozoan parasite emerges as potent therapeutic target: exciting drugs are on the horizon.原生动物寄生虫的线粒体成为有力的治疗靶点：令人兴奋的药物即将问世。
Curr Pharm Des. 2008;14(9):839-46. doi: 10.2174/138161208784041024.
5
ABC transporters and drug resistance in parasitic protozoa.ABC转运蛋白与寄生原生动物的耐药性
Int J Antimicrob Agents. 2003 Sep;22(3):301-17. doi: 10.1016/s0924-8579(03)00210-3.
7
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases?老抗寄生虫药物：它们对于寄生虫感染仍然是可行的选择还是对其他疾病的新选择？
Curr Med Chem. 2020;27(32):5403-5428. doi: 10.2174/0929867326666190628163633.
8
Co-infection of intestinal protozoa and intestinal parasites with Helicobacter pylori among HIV AIDS patients at Jimma Medical Center, Ethiopia.埃塞俄比亚吉马医疗中心艾滋病毒/艾滋病患者中肠道原生动物和肠道寄生虫与幽门螺杆菌的合并感染情况。
Diagn Microbiol Infect Dis. 2025 Jun;112(2):116789. doi: 10.1016/j.diagmicrobio.2025.116789. Epub 2025 Mar 8.
9
[New drugs for the treatment of human parasitic protozoa].[用于治疗人体寄生原虫的新药]
Parassitologia. 2004 Jun;46(1-2):81-4.
10
Chemosensitizers in drug transport mechanisms involved in protozoan resistance.参与原生动物耐药性的药物转运机制中的化学增敏剂。
Curr Drug Targets Infect Disord. 2005 Dec;5(4):411-31. doi: 10.2174/156800505774912875.
引用本文的文献
1
Uncovering the Unusual Inhibition Mechanism of a Trypanosome Alternative Oxidase Inhibitor Displaying Broad-Spectrum Activity against African Animal Trypanosomes.揭示一种对非洲动物锥虫具有广谱活性的锥虫交替氧化酶抑制剂的异常抑制机制。
J Med Chem. 2025 Aug 28;68(16):17155-17174. doi: 10.1021/acs.jmedchem.5c00631. Epub 2025 Jun 4.
2
Deciphering the code of resistance: a genomic and transcriptomic exploration of the Cystoisospora suis Holland-I strain.破解抗性密码：猪等孢球虫荷兰-I株的基因组和转录组学探索
Sci Rep. 2025 Feb 14;15(1):5461. doi: 10.1038/s41598-025-89372-8.
3
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use.抗寄生虫病媒传播疾病药物的环境影响以及将可持续性纳入其研发与使用的必要性。
Open Res Eur. 2024 Nov 4;4:207. doi: 10.12688/openreseurope.18008.2. eCollection 2024.
4
Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools-Chances and Limitations: A Critical Review.运用新型蛋白质组学工具研究抗寄生虫化学疗法：机遇与局限——批判性综述。
Int J Mol Sci. 2024 Jun 24;25(13):6903. doi: 10.3390/ijms25136903.
5
N-methyltubercidin gives sterile cure in a cutaneous mouse model.N-甲基结核菌素在皮肤小鼠模型中实现无菌治愈。
Parasitology. 2024 Apr;151(5):506-513. doi: 10.1017/S0031182024000362. Epub 2024 Mar 27.
6
Use of Bacteriocins and Bacteriocinogenic Beneficial Organisms in Food Products: Benefits, Challenges, Concerns.细菌素及产细菌素有益微生物在食品中的应用：益处、挑战与担忧
Foods. 2022 Oct 10;11(19):3145. doi: 10.3390/foods11193145.
7
In Silico, In Vitro, and Pharmacokinetic Studies of UBMC-4, a Potential Novel Compound for Treating against .用于治疗的潜在新型化合物UBMC - 4的计算机模拟、体外及药代动力学研究
Pathogens. 2022 May 24;11(6):616. doi: 10.3390/pathogens11060616.
8
Two New Antiprotozoal Diterpenes From the Roots of .来自……根部的两种新型抗寄生虫二萜类化合物 。
你提供的原文似乎不完整，句末有省略内容。
Front Chem. 2021 Apr 21;9:624741. doi: 10.3389/fchem.2021.624741. eCollection 2021.
9
Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening.基于结构的虚拟筛选发现二芳基醚取代的四氢酞嗪酮作为TbrPDEB1抑制剂
Front Chem. 2021 Jan 21;8:608030. doi: 10.3389/fchem.2020.608030. eCollection 2020.
10
A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora.从尼日利亚植物群中分离出的天然化合物的抗疟、抗锥虫和抗利什曼原虫活性综述。
Front Chem. 2020 Dec 23;8:617448. doi: 10.3389/fchem.2020.617448. eCollection 2020.
本文引用的文献
1
Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.破坏DNA-蛋白质相互作用并导致布氏锥虫动基体解体的腺嘌呤-胸腺嘧啶特异性小沟结合剂的功能和结构分析
Nucleic Acids Res. 2017 Aug 21;45(14):8378-8391. doi: 10.1093/nar/gkx521.
2
Unpacking 'Artemisinin Resistance'.解析“青蒿素抗药性”。
Trends Pharmacol Sci. 2017 Jun;38(6):506-511. doi: 10.1016/j.tips.2017.03.007. Epub 2017 May 2.
3
Field Evaluation of Two Different Treatment Approaches and Their Ability to Control Fleas and Prevent Canine Leishmaniosis in a Highly Endemic Area.两种不同治疗方法在高流行地区控制跳蚤和预防犬利什曼病的实地评估及其效果
PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004987. doi: 10.1371/journal.pntd.0004987. eCollection 2016 Sep.
4
Exploiting the Achilles' heel of membrane trafficking in trypanosomes.利用锥虫膜运输的致命弱点。
Curr Opin Microbiol. 2016 Dec;34:97-103. doi: 10.1016/j.mib.2016.08.005. Epub 2016 Sep 9.
5
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.印度次大陆流行性内脏利什曼病的进化基因组学
Elife. 2016 Mar 22;5:e12613. doi: 10.7554/eLife.12613.
6
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum.血红素激活青蒿素对恶性疟原虫的混杂靶向作用。
Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111.
7
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.转运蛋白决定了原生动物寄生虫——布氏锥虫对药物的敏感性和耐药性。
Front Pharmacol. 2015 Mar 9;6:32. doi: 10.3389/fphar.2015.00032. eCollection 2015.
8
Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes.对青蒿素耐药的恶性疟原虫在受感染红细胞中表现出不同的发育模式。
Antimicrob Agents Chemother. 2015;59(6):3156-67. doi: 10.1128/AAC.00197-15. Epub 2015 Mar 16.
9
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.布氏锥虫腺苷转运蛋白1（TbAT1）中耐药相关突变的功能分析及该蛋白结构模型的提出
Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21.
10
Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.抗锑的圭亚那利什曼原虫（维扬亚利什曼原虫）中水甘油通道蛋白AQP1基因的染色体内扩增、位点缺失和点突变。
PLoS Negl Trop Dis. 2015 Feb 13;9(2):e0003476. doi: 10.1371/journal.pntd.0003476. eCollection 2015 Feb.
Zotero 插件