工程建模与帕金森病的奥秘。
Engineered modeling and the secrets of Parkinson's disease.
作者信息
Vila M, Wu D C, Przedborski S
机构信息
Dept Neurology, Columbia University, New York, NY 10032, USA.
出版信息
Trends Neurosci. 2001 Nov;24(11 Suppl):S49-55. doi: 10.1016/s0166-2236(00)01984-6.
Abstract
The development of new methods for manipulating the animal genome by transgenic and gene-targeting technologies provides a unique means of studying the most intimate aspects of countless human diseases, including Parkinson's disease (PD). In this review, the contribution of such engineered models to our current understanding of the pathophysiology, etiology and pathogenesis of PD will be discussed.
摘要
通过转基因和基因靶向技术来操纵动物基因组的新方法的发展，为研究包括帕金森病（PD）在内的无数人类疾病的最内在方面提供了一种独特手段。在这篇综述中，将讨论此类工程模型对我们目前对帕金森病病理生理学、病因学和发病机制理解的贡献。
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