Shojai R, Piéchon L, d'Ercole C, Boubli L, Pontiès J E
Service de Gynécologie Obstétrique (Pr L. Boubli), CHU Nord, 15, chemin des Bourrelys, 13015 Marseille.
J Gynecol Obstet Biol Reprod (Paris). 2001 Oct;30(6):572-5.
Assess the efficacy of one misoprostol tablet (Cytotec) in severe delivery-induced hemorrhage on uterine atony after failure of syntocinon.
A descriptive study was conducted at the Djibouti Army Hospital from September to December 2000. Five patients with severe delivery-induced hemorrhage due to uterine atony unresponsive to syntocinon were give a tablet of misoprostol by rectal administration.
The hemorrhage ceased in less than 5 minutes in all patients. No immediate side effect was observed.
These preliminary findings are encouraging and suggest that further investigations would be useful to assess the beneficial effect of misoprostol by rectal administration for patients with severe delivery-induced hemorrhage due to uterine atony. Case-control studies with a sufficient number of cases should be undertaken to determine the real efficacy of misoprostol in this indication.
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