剖宫产时使用口腔米索前列醇预防出血：一项随机研究。
Buccal misoprostol to prevent hemorrhage at cesarean delivery: a randomized study.
作者信息
Hamm Jennifer, Russell Zoi, Botha Tracey, Carlan S J, Richichi Kris
机构信息
Arnold Palmer Hospital for Children and Women, Orlando, Fla, USA.
出版信息
Am J Obstet Gynecol. 2005 May;192(5):1404-6. doi: 10.1016/j.ajog.2004.12.033.
OBJECTIVE
The purpose of this study was to assess the efficacy of buccal misoprostol to decrease uterine atony, hemorrhage, and the need for additional uterotonic agents during cesarean delivery.
STUDY DESIGN
Patients who underwent cesarean delivery were assigned randomly to either 200-microg misoprostol or placebo placed in the buccal space. A dilute intravenous oxytocin infusion was given to all patients at delivery of the placenta. The primary outcome variable was the need for additional uterotonic agents.
RESULTS
A total of 352 women received random assignments. Demographic and intrapartum characteristics were similar between the groups. More women in the placebo group required 1 additional uterotonic agent (43% vs 26%; P < .01; relative risk, 1.3; 95% CI, 1.10, 1.50). There was not a difference between the groups in the incidence of postpartum hemorrhage or a difference in preoperative and postoperative hemoglobin level.
CONCLUSION
Buccal misoprostol reduces the need for additional uterotonic agents during cesarean delivery.
目的
本研究旨在评估剖宫产术中经颊部给予米索前列醇减少子宫收缩乏力、出血及额外使用宫缩剂需求的疗效。
研究设计
接受剖宫产的患者被随机分为两组，分别在颊部放置200微克米索前列醇或安慰剂。所有患者在胎盘娩出时均静脉滴注稀释的缩宫素。主要结局变量为是否需要额外使用宫缩剂。
结果
共有352名女性接受随机分组。两组间的人口统计学和产时特征相似。安慰剂组中更多女性需要额外使用一剂宫缩剂（43%对26%；P <.01；相对风险，1.3；95%可信区间，1.10, 1.50）。两组间产后出血发生率及术前和术后血红蛋白水平均无差异。
结论
剖宫产术中经颊部给予米索前列醇可减少额外使用宫缩剂的需求。
Zotero 插件