Bomba-Opoń D A, Niesłuchowska-Frydrych B, Szucka-May H, Kamiński P, Marianowski L
I Katedry i Kliniki Połoznictwa i Ginekologii AM w Warszawie.
Ginekol Pol. 2001 Dec;72(12A):1377-82.
The aim of this study was to analyze effects of oral administration of conjugated estrogens in women after surgical menopause.
A prospective study that included 41 women after hysterectomy with bilateral oophorectomy, was performed. All patients received conjugated estrogens (Premarin) 0.625 mg daily from second or third days after surgery. Plasma level of estradiol, FSH and several homeostatic parameters were evaluated before and after 2, 5 days and 6 weeks of hormone therapy. The symptoms of climacteric syndrome were estimated based on the scale of Kuppermann.
A decrease in plasma estradiol levels in early postoperative days and an increase up to 100 pg/ml in estradiol concentration after 6 weeks of estrogen therapy were observed. Changes in platelet number, plasma concentration of coagulation factors were transient and there were no significant thrombophilic effects after 6 weeks of Premarin administration.
The postoperative oral administration of conjugated estrogens did not cause thromboembolic complications among women after surgical menopause. Early beginning of estrogen replacement therapy after hysterectomy may prevent symptoms of climacteric syndrome occurrence.
本研究旨在分析口服共轭雌激素对手术绝经后女性的影响。
进行了一项前瞻性研究，纳入41例子宫切除术后双侧卵巢切除的女性。所有患者在术后第二天或第三天开始每天口服0.625mg共轭雌激素（倍美力）。在激素治疗2天、5天和6周前后，评估雌二醇、促卵泡生成素的血浆水平以及几个内稳态参数。根据库珀曼量表评估更年期综合征的症状。
术后早期血浆雌二醇水平下降，雌激素治疗6周后雌二醇浓度升高至100pg/ml。血小板数量、凝血因子血浆浓度的变化是短暂的，服用倍美力6周后没有明显的血栓形成倾向。
手术绝经后女性术后口服共轭雌激素不会引起血栓栓塞并发症。子宫切除术后早期开始雌激素替代治疗可能预防更年期综合征症状的出现。
