Valentini V, Balducci M, Tortoreto F, Morganti A G, De Giorgi U, Fiorentini G
Department of Radiotherapy, Institute of Radiology, Rome, Italy.
Eur J Surg Oncol. 2002 Mar;28(2):180-5. doi: 10.1053/ejso.2001.1161.
Intraoperative radiotherapy (IORT) refers to the delivery of irradiation at surgery. A large single dose of irradiation is delivered to a surgically defined area, while uninvolved and dose-limiting tissues are displaced, the final goal of IORT being enhanced locoregional tumour control. IORT is used in most modern protocol studies as a boost radiation component of multidisciplinary treatment approaches. More recently, high activity radiation sources or mobile operating room treatment machines are used to facilitate the IORT procedure. Clinical experiences have shown that IORT may improve local control and disease-free survival, especially when used in adjuvant setting, combined with external beam irradiation in some neoplasms such as cancer of the stomach, pancreas, colorectum, and soft tissue sarcoma.
术中放疗（IORT）是指在手术过程中进行的放射治疗。将大剂量的单次照射给予手术确定的区域，同时使未受累及的和剂量限制组织移位，IORT的最终目标是增强局部区域肿瘤控制。在大多数现代方案研究中，IORT被用作多学科治疗方法的增强放疗组成部分。最近，高活性放射源或移动手术室治疗机器被用于促进IORT程序。临床经验表明，IORT可改善局部控制和无病生存期，特别是在辅助治疗中使用时，与外照射相结合用于某些肿瘤，如胃癌、胰腺癌、结直肠癌和软组织肉瘤。
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