Frommhold H, Nilles A
Abteilung Strahlentherapie, Radiologische Klinik, Universität Freiburg.
Praxis (Bern 1994). 1996 Mar 5;85(10):295-8.
Intraoperative radiotherapy has proved its worth for curative and palliative treatment of gastrointestinal tumors. IORT indications comprise cancer of the stomach, of the pancreas and colorectal carcinomas. Most authors are cautious to apply it to carcinoma of the esophagus, of the small intestine and of the hepatobiliary system. IORT is applied as adjuvant treatment alone or in combination with postoperative external-beam photon irradiation +/- chemotherapy. There is evidence of an improved local control rate. Pain can be relieved in symptomatic patients by an IORT dose of > or = 20 Gy. Until now, however, there is no evidence of a prolonged relapse-free and overall survival.
术中放疗已证明其在胃肠道肿瘤的根治性和姑息性治疗中的价值。术中放疗的适应症包括胃癌、胰腺癌和结直肠癌。大多数作者对将其应用于食管癌、小肠癌和肝胆系统癌持谨慎态度。术中放疗单独作为辅助治疗应用,或与术后外照射光子放疗+/-化疗联合应用。有证据表明局部控制率有所提高。对于有症状的患者,剂量≥20 Gy的术中放疗可缓解疼痛。然而,到目前为止,尚无证据表明无复发生存期和总生存期会延长。