Furukawa Matakazu, Kashiwagi Shiro, Matsunaga Naofumi, Suzuki Michiyasu, Kishimoto Keiko, Shirao Satoshi
Department of Radiology, Yamaguchi University School of Medicine, Yamaguchi, Japan.
J Comput Assist Tomogr. 2002 Mar-Apr;26(2):272-8. doi: 10.1097/00004728-200203000-00019.
The purpose of this work was to evaluate the usefulness of perfusion CT in the evaluation of patients with chronic cerebral ischemia by comparing it with xenon CT (Xe-CT).
Cerebral blood flow (CBF) of perfusion CT (CBFper) and time to peak (TTP) were compared with the CBF of Xe-CT (CBFxe) in 18 patients. Cerebral blood volume (CBV) was compared with cerebral vascular reserve (CVR) in 10 of 18 patients who underwent pre- and postacetazolamide Xe-CT.
CBFper and TTP demonstrated a high correlation with CBFxe in relative values by side-to-side comparisons (r = 0.743, p < 0.0001 and r = -0.760, p < 0.0001, respectively). There was a negative correlation between relative CBV and relative CVR (r = -0.637, p = 0.0025). Visually, territories with delayed TTP corresponded well to those of decreased CBFxe, but these territories tended to be larger in TTP maps.
Perfusion CT is a useful tool to evaluate chronic hemodynamic disturbance and can be an alternative method for those using acetazolamide challenge.
本研究旨在通过将灌注CT与氙CT（Xe-CT）进行比较，评估灌注CT在评估慢性脑缺血患者中的实用性。
比较了18例患者灌注CT的脑血流量（CBFper）和达峰时间（TTP）与Xe-CT的脑血流量（CBFxe）。在18例接受乙酰唑胺前后Xe-CT检查的患者中，有10例比较了脑血容量（CBV）和脑血管储备（CVR）。
通过左右比较，CBFper和TTP与CBFxe的相对值具有高度相关性（分别为r = 0.743，p < 0.0001和r = -0.760，p < 0.0001）。相对CBV与相对CVR之间存在负相关（r = -0.637，p = 0.0025）。直观上，TTP延迟的区域与CBFxe降低的区域对应良好，但在TTP图中这些区域往往更大。
灌注CT是评估慢性血流动力学紊乱的有用工具，并且可以作为使用乙酰唑胺激发试验的替代方法。
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