Udomphorn Yuthana, Armstead William M, Vavilala Monica S
Department of Anesthesiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA.
Pediatr Neurol. 2008 Apr;38(4):225-34. doi: 10.1016/j.pediatrneurol.2007.09.012.
Traumatic brain injury is a global health concern and is the leading cause of traumatic morbidity and mortality in children. Despite a lower overall mortality than in adult traumatic brain injury, the cost to society from the sequelae of pediatric traumatic brain injury is very high. Predictors of poor outcome after traumatic brain injury include altered systemic and cerebral physiology, including altered cerebral hemodynamics. Cerebral autoregulation is often impaired after traumatic brain injury and may adversely impact the outcome. Although altered cerebrovascular hemodynamics early after traumatic brain injury may contribute to disability in children, there is little information regarding changes in cerebral blood flow and cerebral autoregulation after pediatric traumatic brain injury. This review addresses normal pediatric cerebral physiology and cerebrovascular pathophysiology after pediatric traumatic brain injury.
创伤性脑损伤是一个全球性的健康问题，是儿童创伤性发病和死亡的主要原因。尽管总体死亡率低于成人创伤性脑损伤，但小儿创伤性脑损伤后遗症给社会带来的成本非常高。创伤性脑损伤后不良预后的预测因素包括全身和脑生理状态的改变，包括脑血流动力学的改变。创伤性脑损伤后，脑自动调节功能常受损，可能对预后产生不利影响。虽然创伤性脑损伤后早期脑血管血流动力学的改变可能导致儿童残疾，但关于小儿创伤性脑损伤后脑血流量和脑自动调节功能变化的信息很少。本综述阐述了小儿创伤性脑损伤后的正常小儿脑生理和脑血管病理生理。
