在患有轻度至中度子宫内膜异位症的不孕女性的围排卵期卵泡中，总皮质醇水平降低。
Total cortisol levels are reduced in the periovulatory follicle of infertile women with minimal-mild endometriosis.
作者信息
Smith M P, Keay S D, Margo F C, Harlow C R, Wood P J, Cahill D J, Hull M G R
机构信息
Division of Obstetrics and Gynaecology, St Michael's Hospital, University of Bristol, UK.
出版信息
Am J Reprod Immunol. 2002 Jan;47(1):52-6. doi: 10.1034/j.1600-0897.2002.1o122.x.
PROBLEM
To measure and compare concentrations of total and free glucocorticoids with oocyte fertilizing capacity in the follicular fluid (FF) of women with minimal-mild endometriosis and tubal damage.
METHOD OF STUDY
Follicular fluid was collected from individual periovulatory follicles during oocyte retrieval for in vitro fertilization (IVF) in natural cycles. Total and free levels of cortisol and cortisone were measured using specific radioimmunoassays after chloroform extraction.
RESULTS
Cortisol concentrations in women with minimal-mild endometriosis were significantly lower compared with controls (women with tubal infective damage) (258 versus 328 nmol/L, P < 0.02). There was no correlation between total or free concentrations of cortisol or cortisone and the fertilization capacity of the oocyte.
CONCLUSIONS
Total cortisol levels are lower in the follicles of women with endometriosis. Our findings provide further evidence of follicular dysfunction contributing to the subfertility associated with minimal-mild endometriosis.
问题
测量并比较患有轻度至中度子宫内膜异位症和输卵管损伤的女性卵泡液（FF）中总糖皮质激素和游离糖皮质激素的浓度与卵母细胞受精能力。
研究方法
在自然周期进行体外受精（IVF）取卵时，从单个排卵前卵泡中收集卵泡液。氯仿萃取后，使用特定放射免疫分析法测量皮质醇和可的松的总水平及游离水平。
结果
轻度至中度子宫内膜异位症女性的皮质醇浓度显著低于对照组（输卵管感染性损伤女性）（258对328nmol/L，P<0.02）。皮质醇或可的松的总浓度或游离浓度与卵母细胞的受精能力之间无相关性。
结论
子宫内膜异位症女性卵泡中的总皮质醇水平较低。我们的研究结果进一步证明卵泡功能障碍导致与轻度至中度子宫内膜异位症相关的生育力低下。
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