卵泡液中的类固醇和蛋白质标志物作为有无子宫内膜异位症患者卵母细胞质量的指标。
Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis.
作者信息
Wunder Dorothea M, Mueller Michael D, Birkhäuser Martin H, Bersinger Nick A
机构信息
Department of Obstetrics and Gynaecology, University of Berne, Switzerland.
出版信息
J Assist Reprod Genet. 2005 Jun;22(6):257-64. doi: 10.1007/s10815-005-5149-2.
Abstract
PURPOSE
To investigate the concentrations of steroid hormones (estradiol, progesterone), pregnancy-associated protein-A, IGF-binding protein-4 and leptin in the follicular fluid of infertile patients with and without endometriosis.
METHODS
Follicular fluid of IVF patients with and without endometriosis was aspirated, centrifuged and stored to analyze the above mentioned hormones and to compare their concentrations between women with and without endometriosis.
RESULTS
Follicular fluid estradiol levels were significantly higher in controls than in affected women. The concentrations of the other markers did not differ between the two groups.
CONCLUSIONS
Since not only the follicular fluid concentration of estradiol, but also the oocyte quality is decreased in women with endometriosis, we suggest that estradiol can be considered as a marker not only of oocyte maturity but also of oocyte quality.
摘要
目的
研究有无子宫内膜异位症的不孕患者卵泡液中甾体激素（雌二醇、孕酮）、妊娠相关蛋白-A、胰岛素样生长因子结合蛋白-4和瘦素的浓度。
方法
抽吸接受体外受精（IVF）且有无子宫内膜异位症患者的卵泡液，离心后储存，以分析上述激素，并比较有无子宫内膜异位症女性之间的激素浓度。
结果
对照组卵泡液中雌二醇水平显著高于患病女性。两组间其他标志物的浓度无差异。
结论
由于子宫内膜异位症女性不仅卵泡液中雌二醇浓度降低，而且卵母细胞质量也下降，我们建议雌二醇不仅可被视为卵母细胞成熟的标志物，也可作为卵母细胞质量的标志物。
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