Taylor Alexandra, Wiffen Steven J, Kennedy Christopher J
Department of Ophthalmology, Fremantle Hospital, Western Australia, Australia.
Clin Exp Ophthalmol. 2002 Feb;30(1):47-8. doi: 10.1046/j.1442-9071.2002.00475.x.
This is the first documented case of post-traumatic Scedosporium inflatum endophthalmitis and only the second of S. inflatum endophthalmitis occurring in a non-immunocompromised individual, to the authors' knowledge. A case is reported of a 57-year-old woman who, while chopping wood, had a wood chip hit her in the right eye. This caused a penetrating corneal injury with uveal prolapse and damage to the crystalline lens. There were also vitreous and suprachoroidal haemorrhages. No detectable intraocular foreign material was retained. The clinical manifestation of infection was delayed, but once established, it was very destructive. The initially indolent endophthalmitis eventually led to loss of all light perception and panophthalmitis which required enucleation. The responsible strain of S. inflatum was found to be resistant to all antifungal medication in vitro.
据作者所知,这是首例有文献记载的创伤后膨胀赛多孢菌性眼内炎病例,也是第二例发生在非免疫功能低下个体的膨胀赛多孢菌性眼内炎病例。本文报告了一名57岁女性病例,该患者在砍柴时,木屑击中右眼。这导致了穿透性角膜损伤伴葡萄膜脱垂及晶状体损伤。还出现了玻璃体和脉络膜上腔出血。未发现眼内残留可检测到的异物。感染的临床表现出现延迟,但一旦发生,破坏性极大。最初进展缓慢的眼内炎最终导致完全失明和全眼球炎,需要进行眼球摘除术。体外研究发现,致病的膨胀赛多孢菌菌株对所有抗真菌药物均耐药。