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[与抗GD1b IgG抗体相关的共济失调型吉兰-巴雷综合征]

[Ataxic form of Guillain-Barré syndrome associated with anti-GD1b IgG antibody].

作者信息

Ichikawa H, Susuki K, Yuki N, Kawamura M

机构信息

Department of Neurology, Showa University School of Medicine.

出版信息

Rinsho Shinkeigaku. 2001 Aug;41(8):523-5.

Abstract

A 28-year-old man was admitted after developing acute onset unstable gait following acute enteritis. Neurological examination revealed mild weakness in four limbs, areflexia and ataxia. Serum obtained from the patient during the acute stage contained a high titer of anti-GD1b IgG antibody. Because the patient showed obvious cerebellar ataxia unrelated to muscle weakness, without ophthalmoplegia or proprioceptive sensory disturbance, we concluded that he had ataxic form of Guillain-Barré syndrome (GBS) (Richter, 1962). Although ataxic GBS is not an established conception, one should pay attention to the possible existence of such a rare GBS variant. It is necessary to accumulate additional case reports to clarify the association between ataxic GBS and anti-ganglioside antibodies.

摘要

一名28岁男性在急性肠炎后出现急性发作的步态不稳,随后入院。神经系统检查发现四肢轻度无力、腱反射消失和共济失调。急性期患者血清中抗GD1b IgG抗体滴度很高。由于患者表现出明显的与肌无力无关的小脑共济失调,无眼肌麻痹或本体感觉障碍,我们诊断他患有共济失调型吉兰-巴雷综合征(GBS)(Richter,1962年)。尽管共济失调型GBS并非既定概念,但应注意这种罕见的GBS变异型可能存在。有必要积累更多病例报告以阐明共济失调型GBS与抗神经节苷脂抗体之间的关联。

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